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KMID : 0375219950100010031
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Journal of Il Sin Christian Hospital
1995 Volume.10 No. 1 p.31 ~ p.42
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Bone Mineral density & Biochemical Bone Marker Study in Perimenopausal Women
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Abstract
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To investigate bone markers to predict the bone loss rate in perimenopausal women, we measured serum osteocalcin(bone gla protein), total & bone specific alkaline phosphatase as bone formation markers and urinary deoxypyridionline as bone
resorption
marker in 79 perimenopausal women.
@ES Our results were as follows:
@EN 1. In 79 patients , the average of the BMD of L2-4 was 1.073±0.16g/㎤, the BMD of femur neck 0.863±0.11g/㎠, the T-ALP 139.87±59.41IU/L, the B-ALP 81.78±39.9IU/L, the S-osteocalcin 5.46±2.09ng/ml, and the U-PYD 9.81±9.13 nmol/nmolCr.
2. S-osteocalcin(r=-0.461) and B-ALP(r=-0.358) showed best correlation with the BMD.
3. Correlations between each bone marker were all significant (r>0.45, P<0.01), while T and B-ALP showed strongest correlation with each other. (r=0.8167).
4. As age increased, BMD decreased and all bone markers except U-PYD increased.
5. BMD of L2-4 and 4 bone markers on premenopausal women varied from that on postmenopausal women significantly
From our results in perimenopausal women, biochemical bone markers are consistent and tell us meaningful information about BMD. However, more broad and well-controlled, prospective studies are needed to get more accurate and sensitive results.
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KEYWORD
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